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HIV protease inhibitors Sep 22, 2006 Could you tell me the spectrum of activity and the mechanism of resistance for the antimicrobial HIV protease inhibitors (Ex: Indinavir)and do they work with gram positve/gram negative bacteria. What bacteria does it work against. Or what sites I can go to find the answeres? Thank you |
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Response from Dr. Daar
 The HIV protease inhibitor selectively blocks the protease enzyme and prevents an infected cell from producing infectious HIV. Resistance develops when mutations emerge in the viral protease enzyme that prevent the inhibitor from interacting with the enzyme and blocking its function. These drugs are not active against bacteria or other viruses. Best, Eric |
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