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Where's that One-Pill-a-Day?
Apr 28, 2006

Hi, Dr. Daar -

Great responses to all your questions, clear and (wonderfully) optimistic! I am currently on Sustiva and Truvada with fantastic results (undet., 795 CD4) for the last 2 years, and am curious when we can expect to see that good-ol' one-a-day combo pill we've been hearing so much about? Go, Bruins!('88)

Best wishes, Matt

Response from Dr. Daar

Hi Matt, Thank you for your supportive comments and your question.

Great news on your success with therapy! The other good news is that the one pill a day combination of the drugs in TruvadaTM (tenofovir and emtricitabine) with SustivaTM is right around the corner. In fact, just yesterday Gilead (the makers of TruvadaTM) and BMS (the makers of SustivaTM) sent out a press release announcing the submission of the "new drug application" for FDA approval of the single tablet. The data showing that you achieve similar blood levels in those taking these medications as a single pill as those taking them separately holds great promise for this new formulation. The companies are hoping for rapid review and approval by the FDA; however, the actual date of approval is not known.

It is worth noting that while more convenient, which is important; there is nothing else magical about this medication. It will be appropriate for people who otherwise would have been candidates for treatment with TruvadaTM and SustivaTM or those currently on this regimen (like you) who want to simplify from two pills to one pill once-daily. In addition, there is little reason to believe that there will be any differences in the side effects associated with this medication from the older formulations.

This advance continues the trend over the last few years of increasingly simple regimens being available to treat those with HIV infection. From my perspective, it is all good!!

Best, Eric


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