Please Note: Due to volume considerations, not all questions can be answered. Questions most likely to be answered will be those of general interest to a broad group of visitors to this forum. Questions pertaining to a specific case; requests for diagnosis, medical advice, or second opinion; or requests for opinions about untested alternative therapies will generally not be answered.
The participation of Dr. Joseph McGowan in this
Forum is made possible by Boehringer Ingelheim.
|
|
 |
|
compatible
Mar 22, 2007
Dr. Daar,
I read about the drug contraindication of trizivir, trizivir is containdicated to viracept. But 3 years ago my doc. put me on viracept and trizivir, even if I'm tolerating it well I am abit worried that I shouldn't have been taking it.
can anybody give me an idea? Thanks.
Mary.
|
 |
|
 |
|
Response from Dr. Daar
Hi Mary,
If I have your comments right, you are concerned about current recommendations regarding the use of trizivir (ZDV/3TC/Abacavir) and the fact that you are currently on trizivir and viracept (nelfinavir).
What I suspect you are referring to is that current guidelines state that trizivir should not be used as primary therapy for patients unless they are unable to be treated with an NNRTI or PI-based regimen. The reason for this is that while trizivir is actually fairly effective it is clearly not as good as a NNRTI or PI-based regimen. Furthermore, this recommendation applies to trizivir alone, not with a PI or NNRTI.
Nelfinavir is an effective PI and while it is no long recommended as a preferred PI for treatment naive subjects, it is listed in most guidelines as an alternative. The reason for this is again not because nelfinavir does not work, as it clear does, but because it is not as effective as other ritonavir-boosted PIs.
For someone who is on a nelfinavir-containing regimen with good tolerance and prolonged virologic suppression there is no urgent need to make a change. Certainly discussions should occur on an ongoing basis between the patient and an expert provider as to available options, the ultimate decision is really up to the patient as to whether to switch or stay on treatment. In your case the other issue to discus with your provider is the need to be on trizivir with a PI versus just two NRTIs with the PI. Again, these discussion must be in the context of how you are doing on your current regimen.
I hope that helps.
Best,
Eric
|
|
|
 Please remember that this forum is designed for educational purposes only, and experts are not engaged through this
forum in rendering legal or medical advice or professional services. Experts appearing on this page are independent and are solely responsible
for editing and fact-checking their material. Neither The Body nor any sponsor is the publisher or speaker of posted visitors' questions or the experts' material.
Questions and messages posted to this forum are not statements of advice, opinion, or information of The Body, Body Health Resources Corporation or any sponsor of this
forum. While neither The Body nor Body Health Resources Corporation regularly reviews posted content, we reserve the right to delete, move, or
edit postings if we deem it appropriate under the circumstances. Visitors submitting questions remain solely responsible for the content of their
messages.
Information provided by experts is general only and should not be used for diagnosing or treating a health problem or a disease, or relied upon as
legal or other professional advice. This information is not a substitute for professional advice or care. If you have or suspect you may have a
health or legal problem, you should consult your own health care provider or your attorney.
Copyright notice.
|
|
|
|
