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Back to Crixivan and Copmbivir

Nov 27, 2004

Dear Dr My history VL 258000 ct4 48, after 6 months on Crix. and Comb. VL less then 400 CT4 236. Change to Crix. with Norvir two time daily + Comb no food restriction,after another 6 months VL less then 50 ct4 results next week, not much side effects, filling gteat, but now another problem. Im in S. Africa and now Abbott here start to sell Norvir(100) after original sticker date of expire 11.2004 they putting over that new sticker with new expire date 11.2005 But on Abbott web site they say Norvir must not be used after exp. date,because it is soft gel capsule. I understand shelf life for tis capsule is 1 year? My Q is can I go safe back to Crix. 3xdaily(800)no food with 2xdaily Comb. like I used first 6 months till this problem with Abbott is solved in South Africa and they come with new stock. Dont like it with food restriction,but what else I can do? Thank you on your help!

Response from Dr. Lee

There are probably other options for therapy, but I am not familiar with your situation. So, if you can get the full dose (300mg every 8 hrs) of the Crixivan and you can stick with the dosing and food restrictions until options are available, I agree that you should. Remember the Combivir is every 12 hrs, so you really take a dose of medicine four times daily. Ex: 7 AM (1 hour before breadfast) Crix & Comb, 3PM (2 hours after lunch) Crix, 7 PM (Ok with or without food)Comb, 11 PM (on an empty stomach) Crix. Difficult, but doable for some folks, particularly if it is only for a while.

Be well.

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