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Switching to Once Daily Trizivir

Dec 23, 2003

I am on a combination of Trizivir and Sustiva and my numbers are good. Viral load is <50 and and CD4 is 600.

I recently read online about a study where patients taking once daily abacavir (600 mg) along with with once daily 3TC + Sustiva have the same viral suppression results (<50 in over two thirds) as those on "twice" daily abacavir regimens.

My question is, does this mean I can take "both" of my Trizivir pills at night along with my Sustiva?

Thanks for any insight you can give.

Response from Dr. Boyle

Although AZT is clearly a twice-daily drug, abacavir and lamivudine appear to have pharmacokinetics which support once-daily therapy. Therefore, you should be able to get away with taking the 2 Trizivir once-daily with Sustiva. However, you should discuss this with your doctor before embarking on this change, since for some patients it may be inappropriate, and you should also discuss with your doctor whether you can simplify to abacavir + lamivudine + Sustiva (getting rid of the zidovudine) which could decrease side effects, limit long-term toxicities and save money.

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