Efficacy of trizivir as sole hiv treatment after 5 year of triple combination
Apr 28, 2003
Based on current clinical research and your professional practice, does taking triziver alone provide long-term benefits of keeping viral loads undetectable?
Response from Dr. Boyle
The best study performed to date to examine the efficacy of Trizivir (abacavir + zidovudine + lamivudine co-formulated tablet) is ACTG 5095. The data safety monitoring board (DSMB) stopped the Trizivir arm of that study due to its significant underperformance of the 2 Sustiva/Stocrin (efavirenz) containing arms of that study, one that is Sustiva/Stocrin + Combivir (zidovudine + lamivudine co-formulated tablet) and the other Sustiva/Stocrin + Trizivir. There were several factors cited by the DSMB in making this decision including the significantly lower number of patients on Trizivir alone who achieved <200 copies/mL (the ACTG cutoff) at 48 weeks and the higher rate of failure per 3 months associated with the Trizivir arm. Using an intent to treat analysis (with switches NOT counting as failures), patients in the pooled Sustiva/Stocrin arms had 89% reach <200 copies/mL at 48 weeks versus only 74% of the patients treated with Trizivir and the failure rate (per 3 months) was 3.5% among the patients in the pooled Sustiva/Stocrin arms versus 7% in the Trizivir arm. The conclusion of the DSMB is that Trizivir is inferior to the Sustiva/Stocrin containing regimens. These data from this large, well done study would certainly indicate that relative to Sustiva/Stocrin regimens, Trizivir is not as effective at providing "long-term benefits of keeping viral loads undetectable."
Get Email Notifications When This Forum Updates or Subscribe With RSS
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.