Oct 27, 2002
Dear Dr Boyle, Thanks for answering this question. I am very worried as I have just changed meds from sustiva/combivir to Viramune/combivir and have just started my new meds. Are there any concerns that I should be aware off in the early days of taking this combo and what are my chances of being able to tolorate this new med, many thanks for the advice.
| Response from Dr. Boyle
In general, Viramune is pretty well tolerated, but you must watch out for 2 potential toxicities. The main toxicities of Viramune (nevirapine) are related to liver toxicity and rash. Some degree of liver toxicity occurs in a significant number of patients treated with Viramune, but it is uncommon for it to be severe. Your doctor should monitor your liver enzymes every 2 weeks or so during the intial treatment period and then every month or so. You should also watch for symptoms suggestive of liver toxicity such as a non-specific flu-like illness, fatigue, malaise, loss of appetite, nausea or jaundice and, if they occur, they should be immediately reported to your doctor. If you develop a rash, you should also contact your doctor immediately since Viramune related rashes can be severe in some patients and progress to a life-threatening condition if Viramune (nevirapine) is not appropriately discontinued.
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