|Switch from Rescriptor to Viramune?
Oct 16, 2002
I recently discontinued Sustiva because of psychological problems it was causing (VL<50, T-Cells high 500's). My physician substituted Rescriptor for the Sustiva, and continued my previous Nuke regimen of Combavir. Now I am experiencing night sweats, fevers and chills. I previously had taken Viramune, along with Combavir, for approximately 4 years, with good results, but gave up the Viramune because of lipodystrophy concerns. If my regimen is failing because of the Rescriptor, can I resume treatment with Viramune, or have I developed resistance to this entire class? I have never taken a P.I. Thank you so much for your attention to this question.
| Response from Dr. Boyle
With the information you provide, it's tough to know whether the NNRTI class is blown of not. If you are still <50 on the Rescriptor-Combivir regimen, and have remained so throughout your treatment, it may be possible to switch back to Viramune. If not, then you should be careful of such a switch since resistance may have developed to part of the regimen, including the NNRTI.
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