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Almost Undetectable

Jun 12, 2002

I began therapy about nine months ago(Sustiva, Epivir and Videx). When I started my VL was 331,000 and T-cells were 240. Within a month, VL was 3,300 and T-cells were 300. Basically, it continued to get better - slowly, with a few ups and downs on the VL. I got below 400 copies on the VL but couldn't get under 50 where my doctor very much wants me to be. So we added Viread about 7 weeks ago. First VL reading after adding Viread was 60 and today it was 84. While very very close, I'm not at the "gold standard" of below 50 on the VL. It's really frustrating! I'm 100 compliant! Any thoughts on why I'm not there yet? Do some people just take longer? And - most importantly - is this a bad sign for how I will respond to treatments going forward? By the way, we're going to do one more reading in about a month. If I'm not below 50, doc wants me to go on my first PI - likely Kaletra - along with the Viread and Epivir. What do you think of that potential new combo? Finally, thank-you. You are heros.

Response from Dr. Boyle

This is an area where information is very limited. While some studies have indicated that getting below 50 copies/mL (or <20 copies/mL in one study) is more likely to lead to durable success, others have not. Further, some studies have found that in patients with high viral loads (>100,000 copies/mL) it may take longer than the usual cutoff of 6 months to get to <50. If you're tolerating the regimen well, I don't know that I would be so quick to change you, especially if you consistently stay in the <400 range. Another point is that the combination of Videx (didanosine) and Viread (tenofovir) leads to significant elevations in the Videx levels. You should discuss this with your doctor since your dose of Videx may need to be adjusted.

Tenofovir & Didanosine Dosing

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