I have read many studies regarding this topic. Can using poppers reduce my cd4 or keep it more suppressed? or are there no real studies to prove this? I enjoy the use of them, but I wouldn't say on a regular basis. Maybe 4 times a month.

There is no consensus on this topic but the most recent major study, the Multicenter AIDS Cohort Study (MACS) published in a peer-reviewed journal in 2008, found no "clinically meaningful associations between use of [several other drugs and] poppers and CD4 and CD8 T cell counts, percentages, or rates of change in either HIV-uninfected or -infected men." This contradicted earlier research indicating such an association, as well as numerous anecdotal accounts. Even if one sets aside concerns about CD4 counts, however, poppers have other risks, notably a fall in blood pressure, increased heart rate, and weakness or dizziness. Using poppers with erectile dysfunction drugs can cause a dangerous drop in blood pressure resulting in fainting or even heart attacks and stroke. Appropriate cautions should be taken.