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Pulsing??
Jul 24, 2001

On 7/20/01 there was an article in the NYTimes that experts caution that sti's don;t work and people are getting sick.This was from a 2day conf in Chicago?? Has this data changed your thoughts on pulsing and what are your latest thoughths on pulsing?

Response from Dr. Boyle

I have never been an advocate of STI; however, "pulsing" therapy, such as through structure intermittent therapy, may be as effective as continuous therapy but may decrease the amount of time on medications, risk of toxicities and cost. In some of these studies, antiretroviral therapy one week on and one week off appears to be as effective as continuous therapy, but the studies are at a very early stage and it is too early to make any definitive conclusions as to whether or not they work. Therefore, noone should change their medications at this time, but further data should emerge over the next few years that inidcate whether or not this strategy will work.



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