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Switching Off PI

Jul 18, 2001


My partner has been HIV+ for more than 10 years. He started on AZT monotherapy for awhile, then Videx monotherapy. Then came HAART. On D4T, 3TC and Crixivan for almost 3 years with excellent results. The Crix was switched to Nelfinavir for ease, but he more frequently will take it without food, and that has me worried. Would it be better to have him switch to something like Sustiva or Nevirapine rather than risk resistance, or am I being overly worried?

Thanks for your help.

Response from Dr. Boyle

Switching is not a bad idea, but I'd need more information. If he is doing fantastically well on the nelfinavir (Viracept), I would consider continuing it and working on getting him to take it with a snack, candy bar or something. On the other hand, given the problems you have described, I'd have qa very low threshold for changing his regimen to something else, such as a boosted protease inhibitor, Sustiva/Stocrin (efavirenz) or Viramune (nevirapine) regimen.

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