Dec 19, 2001
I started a new regimen of drugs about two weeks ago that include: Kaletra,Viread,Combivir,SMZ-TMP DS, and a Zithromax megadose once a week. Since starting this regimen, I cannot fall asleep. I yawn a lot and feel tired and exhausted, but cannot sleep. Which med(s) might cause this side affect?
Response from Dr. Henry
A significant percentage of people starting those drugs will be out of sorts in a non-specific way for many weeks. None of those drugs are associated with a significant rate of sleep disorders (< 1-2%) but they can occur. Increasing your exercise and avoiding caffeine and alcohol can help some people. Hormonal disturbances, drug interactions, stress, depression and other conditions can also impact sleep patterns. Again, taking those drugs is quite a whallop to your body/brain which can take many weeks to equalibrate. I sometimes prescribe trazadone or a short acting sedative to patients in this setting for a month or so to help out. Some people sleep better taking benadryl and/or 3 mg melatonin tables. If your problem continues you need to discuss with your HIV doc.
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