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BMS & Lipodistorphy
Oct 31, 2001

Will the new PI from BMS have come without the possibility of Lipodistorphy? I mean what I hear it does not casuse a rise in lipids so I am assuming it will be ok.

Response from Dr. Henry

Limited data so far does suggest that the BMS protease inhibitor in development (atazanavir) has not been linked to the rises in cholesterol/triglycerides seen with some of the other protease inhibitors. I have not seen much regarding change in body fat distribution. There is hope that atazanavir will hold up as a PI that is fat/lipid friendly which would be an attractive feature along with once a day dosing. More experience with the drug will be necessary to validate those early observations. KH



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