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high MCV and MCH
Oct 20, 2001

I have been on Meds for 5yrs doing great. I have been told by my Doctor to take folate for high MCV and MCH. Hasn't been effective. Is there a maximum safe dose. Is there other approaches to correct this.

Response from Dr. Henry

Patients taking AZT or D4T as a part of their antiretroviral regimen often develop high MCV/MCH values. Rarely is that associated with any clinical manifestations. To my knowledge, taking folate in the absence of documented folic acid deficiency rarely accomplishes much. I have not seen any data that any intervention referses those lab abnormalities as long as D4T/AZT are still used. I generally don't worry about those lab abnormalities assuming good nutrition and vitamin levels. KH

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