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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
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Wellbutrin & PI
Aug 4, 2000

I'm a psychiatrist, but I'm new to the HIV field. Some of my HIV-positive depressed patients do seem to need antidepressants. Trouble is, SSRIs cause sexual dysfunction to become worse - no ejaculation. Wellbutrin seems the only effective drug without this problem. But if it cannot be taken with PIs...imagine how depressing it is to be told that! Why are SSRIs safe with PIs? Won't PIs elevate blood levels of SSRIs and cause severe side effects?

Response from Dr. Henry

PIs (esp ritonavir which is increasingly used as a 2nd PI for pharmacologic enhancement) can inhibit the cytochrome p450 enzyme system in the liver. Caution needs to be used when combining PIs with other medications that are metabolized through that enzyme system. The interaction can be bi-directional and complicated. To make matters worse, there is little published pharmacokinetic data that could guide decision making. One study looking at Effexor found somewhat lower levels of the PI which could be a problem from the HIV perspective. I do have a few patients on Wellbutrin and PIs but we try to watch closely. Seizures due to Wellbutrin are dose dependent so drugs (ie PIs) that inhibit metabolism can increase the risk for seizures -- that is the concern as far as I know. Using a low dose and watching carefully are the common sense precautions when the drugs are used together. Keith Henry, M.D.

intestinal distress
Off of Hydroxyurea

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