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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
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abacavir-induced diabetes
Sep 11, 2000

Recently, we have had a HIV patient treated with ddI, d4T and abacavir who developed a ketoacidotic situation in the context of a hyperglycemic state. We have notice of some cases of mild hyperglycemia during treatment with ddI; but in our case diabetes disappeared when abacavir was retired. Do you have any other comments? Is it related with mitochondrial toxicity? Thanks from spain

Response from Dr. Henry

Your case is very interesting but unusual in both my experience with abacavir and with Glaxo-Wellcome's abacavir experience. Abacavir generally falls on the low end of the scale for mitochondrial toxicity so that would seem like an unlikely mechanism. I will keep my antennae up for other reports like yours. KH

Keith Henry, M.D.

Restarting Abacavir after Drug Holiday
Mastocytosis and HIV

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