Sep 11, 2000
Recently, we have had a HIV patient treated with ddI, d4T and abacavir who developed a ketoacidotic situation in the context of a hyperglycemic state. We have notice of some cases of mild hyperglycemia during treatment with ddI; but in our case diabetes disappeared when abacavir was retired. Do you have any other comments? Is it related with mitochondrial toxicity? Thanks from spain
| Response from Dr. Henry
Your case is very interesting but unusual in both my experience with abacavir and with Glaxo-Wellcome's abacavir experience. Abacavir generally falls on the low end of the scale for mitochondrial toxicity so that would seem like an unlikely mechanism. I will keep my antennae up for other reports like yours. KH
Keith Henry, M.D.
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