Sep 11, 2000
Recently, we have had a HIV patient treated with ddI, d4T and abacavir who developed a ketoacidotic situation in the context of a hyperglycemic state. We have notice of some cases of mild hyperglycemia during treatment with ddI; but in our case diabetes disappeared when abacavir was retired. Do you have any other comments? Is it related with mitochondrial toxicity? Thanks from spain
Response from Dr. Henry
Your case is very interesting but unusual in both my experience with abacavir and with Glaxo-Wellcome's abacavir experience. Abacavir generally falls on the low end of the scale for mitochondrial toxicity so that would seem like an unlikely mechanism. I will keep my antennae up for other reports like yours. KH
Keith Henry, M.D.
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