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HIV in Diabetics
Sep 25, 2001

My Dad has been a Diabetic for over 16 years. He has been recently detected to be HIV Positive with a viral load of 1,50,000 and CD4 Count of 0.03. He is at present undergoing treatment for tuberculosis. Can he put on Anti-Retroviral Drugs please advise

Response from Dr. Bartlett

Antiretroviral therapy can be complicated in patients with diabetes and those on antituberculous treatment. Protease inhibitors can rarely cause or worsen diabetes, and therefore using this class of drugs will require close follow-up. In addition, the protease inhibitors may interact with rifampin or rifabutin, 2 drugs commonly used to treat tuberculosis. It may be more sensible to use a regimen that does not contain a protease inhibitor, specifically either 2 NRTI and an NNRTI, or 3 NRTI. I strongly suggest consulting with his health care provider to weigh out the pros and cons of each option.

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