|Skin pigmentation changes in people of color
Aug 21, 2001
Do some antiretrovirals cause darkening or irregular pigmentation changes in people of color? If so, which ones?
| Response from Dr. Henry
I have seen darkening of skin mostly due to zidovudine and some of the other nucleoside reverse transcriptase inhibitors. I have seen dryness of the skin and nail problems with the protease inhibitors such as indinavir. Generally the darkening of the skin (and dark coloring in the finger/toe nails) is reversible when the medication is stopped. Often the patient determines that the benefit of the therapy outways that annoying side effect--that depends on the individual situation and health beliefs of the patient (every situation and person is unique!). KH
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