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ANTIRETROVIRAL HEPATOTOXICITY
Aug 11, 2001

CAN KALETRA,DDI AND D4T CAUSE SEVERE HEPATOTOXICITY, IN A PATIENT WITH HEPATITIS C CONINFECTION? IF YES, WHAT KIND OF HEPATIC DAMAGE?

Response from Dr. Henry

Yes those drugs can either individually or in combination cause a form of drug induced hepatitis that would be more common inpatients with hepatitis C infection. Among the protease inhibitors ritonavir has been most associated with drug induced hepatitis (somewhat dose related but can occur even with the low dose found in Kaletra). The "d" drugs can possibly cause hepatic steatosis/lactic acidosis as well which may be more common in patients with pre-existing liver abnormalities including hepatitis C. Those drugs can be used in persons with hepatitis C but more careful monitoring of liver status is wise. KH



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