Jul 20, 2001
Dear Doctor, below I copied the question and your answer. Please clarify your last statement. Which drugs are safe and work as of sommer 2002? diabetic drugs for lipodystrophy or antiviral combination? Thank you Jack lypoatrophy Posted: Jul 11, 2001
Dr Keith Henry, what are the potential dangers of using diabetic drugs re lypoatrophy if one isnt a diabetic? Thanks,
A major concern relates to liver toxicity and the risk for lactic acidosis. There is also concern about hypoglycemia. Any kidney dysfunction could increase the risk for those complications. There is also concern about use in persons with heart failure or using drugs which might interact. GI complaints are fairly common which can complicate the use of anti-HIV medications. As of summer 2001, there is scant evidence that use of these drugs works and is safe. KH
Response from Dr. Henry
Sorry if my earlier reply was too technical. To make a long story short, none of the diabetic drugs have been proven safe and/or effective in treating lipoatrophy seen in the setting of treated HIV infection. Metformin and the class of drugs called the glitazides (such as rosiglitazone) are being studied by the ACTG (AIDS Clinical Trial Group) but data is too limited to comment as to the effectiveness and safety. We'll have to be patient for the results of some more studies to become available to guide us in that manner. KH
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