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Viagra and HIV meds?
Jun 22, 2001

Are there any documented interations between Viagra and any antivirals. In particular, I've heard there could be one with Kaletra?

Response from Dr. Boyle

Drugs that inhibit the enzymes that metabolize Viagra will increase Viagra levels and those that induce those enzymes will decrease Viagra levels. Inhibitors include Rescriptor (delavirdine) and ritonavir (which is present in Kaletra and also frequently used in combination with indinavir and saquinavir). Inducers of the enzymes include Sustiva/Stocrin (efavirenz) and Viramune (nevirapine). The package inserts for Rescriptor, Norvir and Kaletra all warn about the interaction (that is, that it may lead to high levels of Viagra and significant side effects and problems) and recommend caution and a dosage adjustment.

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