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Treatment for Progressive Leukoencephalitis
Nov 1, 1996

Dear Dr. What is the "drug of choice" for treating progressive multifocal leukoencephalitis? Thank you. babineau@freenet.msp.mn.us

Response from Dr. Cohen

The treatment of choice for treating progressive multifocal leukoencephalopathy (PML) is good antiretroviral therapy. The two drugs that have been used most extensively for this condition are alpha interferon and cytarabine (ARA-C); however, neither has shown much promise. When therapy works, it is usually in people with relatively high CD4 counts (over 200), and those people (who rarely get PML to begin with) sometimes do well even without therapy. Thus, the best thing you can do for someone with PML is to improve their CD4 count.



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