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botox to reduce parotid gland hypertrophy
Mar 14, 2014

is it possible to use botox to treat the parotid gland and jaw hypertrophy associated with hiv / medications? if so, what are the costs associated with such treatment? thank you for your time,

Response from Dr. Henry

I am unaware of any published clinical trial data on use of botox for parotid gland hypertrophy in the setting of HIV infection. If any reader is aware of a paper on the topic or has personal experience please post.

There are anecdotal reports of botox being effective in this setting. There is a clinical trial in Vancouver that has enrolled (NCT01635504) with the following objective:

he investigators plan to study posterior cheek enlargement in HIV positive individuals. The investigators also plan to use botulinum toxin A as a novel treatment to improve the altered lower facial contour seen in HIV. This treatment has already demonstrated efficacy in HIV negative individuals with enlargement of the masseter muscle. Botulinum toxin has also been used safely in the salivary glands in individuals with excessive drooling resulting from neurological disease. In a trial HIV+ patient, the investigators have already demonstrated the efficacy of using botulinum toxin A in the treatment of posterior cheek enlargement, resulting from both parotid and masseter muscle enlargement. The investigators anticipate this study will increase our understanding of posterior cheek enlargement in HIV and lead to the development of a novel treatment for this important complication.

The investigators hypothesize that posterior cheek enlargement in HIV+ patients will in some cases result from both masseter muscle hypertrophy as well as parotid gland enlargement. The investigators also hypothesize that the treatment of posterior cheek enlargement with botulinum toxin A will result in a more aesthetically appealing lower facial contour in HIV+ patients. This has already been demonstrated in a trial HIV+ patient, in which there was a dramatic change in the volume of the masseter muscle and parotid gland 12 weeks after treatment with botulinum toxin A.

KH



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