|HAART and CDL license
May 9, 2001
I have been on Norvir/Fortovase,Epivir and Zerit for 3 years since my diagnosis, still undetectable, with CD4s in the 250 range (12 percent). I am also on anabolic steroids (Anadrol,Androgel) in cycles, which have helped tremendously with muscle mass, energy. I would like to get a CDL license and try over the road trucking, but the side effects from the current regimen would make that unsafe - the drugs make me tired and feeling slightly intoxicated for at least an hour or two after taking them. Since I have advanced disease, effectively under control, I'm concerned about switching from meds that are working; however, are there any effective combos available which would likely keep the HIV under control, but without side effects that would compromise driving safety?
| Response from Dr. Henry
Your regimen is not one that usually exhibits CNS side effects (as opposed to say Sustiva which is a good drug but may cause odd dreams and interfere with sleep). For some folks ritonavir gives them a drugged feeling (esp at higher doses like 400 mg BID which is often used with Fortovase). You might consider trying a boosted regimen with a lower dose of ritonavir and see if that helps (ie Kaletra which features 100 mg ritonavor twice a day). That should still be a strong PI based regimen for you. Agenerase 600 with ritonavir 100 or 200 mg BID could also be considered. Switching off a PI to something like nevirapine or abacavir could also be considered. KH
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