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Managing Lipodystrophy
Aug 28, 2013

I saw bits of information about a compound called R- ALPHA LIPOIC ACID, as a naturally occurring fatty acid, which in Europe has been used to lower blood sugar in patients with high level of blood sugar, thus increasing insulin sensitivity by am impressive margin of 25% in a month time. Can this be used in US, for HIV/AIDS patients, against lipodystrophy?

Response from Dr. Henry

I have seen no data published from a good clinical study looking at a-lipoic acid (often touted for its anti-oxidant effects)for treatment of lipodystrophy ( a term often encompassing both fat distribtion problems-both extra or loss of fat) and increased fats in the blood. Agents like metformin that are used for diabetes (believed to increase sensitivity to insulin) have been studied in the setting of HIV-related fat problems with some positive results but in other studies a mixed picture with some side effects. If any reader knows of a good study published using a-lipoic acid for HIV-related lipodystrophy please post. KH

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