Aug 24, 2013
I'm currently on PI monotherapy and doing well. I have this regimen for a year now. I started with Atripla but developed a rash after 2 weeks and was withdrawn. My second regimen was Truvada, Reyataz and Norvir but I needed to stop due to kidney toxicity. Next option was Epzicom but I'm positive for the genetic mutation that increases the odds of an allergic reaction to the Ziagen. Now as far as this therapy works everything is fine but my concerns are a failure. I'm 100% adherent and I never missed a dose. If this therapy would stop working what other options are available? I don't have any resistance issues. My doc mentioned Combivir but I'm afraid of the AZT and its link to lipoatrophy. What drugs would you consider? Thanks for your advice.
Response from Dr. Henry
Avoiding resistance in your situation makes sense with the limitations available regarding NRTI choices. Might consider adding an integrase inhibitor such as raltegravir or the newly approved dolutegravir. KH
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