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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
          
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Atripla and Liprodistropy
Aug 21, 2013

I have been HIV + almost 15 years now and AIDS diagnosed for nearly 10. I did not have a proplem with Atripla at first but...now the severe weight gain (Liprodistropy) (over the last 4-5 years has gotten out of hand ! I've gain 30 plus lbs. maily in my stomach area. It is depressing and not good I know but I've tried dieting, eating less, and try to stay as active as possible even though that difficult with my neruotopy. Is there any feesable solution or suggestion to help get some of this weight off. Have discussed this with my Dr. and they just keep telling me it's my medications.

Response from Dr. Henry

The risk for HIV related fat problems is related to history of low CD4 count, genetics, duration of time with HIV, history of HIV treatment (which drugs), and other factors (many of those factors cannot be changed unfortunately). Determining if the fat is subcutaneous or intraabdominal (CT scan) sometimes is helpful to understand an individual patients situation. Atripla compares well to many other HIV regimen regarding impact on fat gain though it still happens. I am not confident that I could recommend a switch to another regimen with a clear decreased in fat thereafter. Fat issues remain a vexing problem in the field. If other similarly aged or older family members without HIV have increased abdominal fat then the genetic component may be strong in your case. Use of drugs like growth hormone or GH-releasing factor can help some but that is expensive, has side effects, has to be given as a shot, and the modest benefit reverses when treatment stopped.KH



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