Persistant side effects though 2 switches
Jul 9, 2013
Hello Dr Henry, I took Atripla as a first treatment during about two months, had to stop because of severe depression induced by the treatment + insomnia, important weight loss and severe headaches. My doctor switched me to Reyataz/Norvir/Truvada. The mental state was better for a month or so, except the persistent insomnia and a mild anxiety. But I then also had to stop because of liver intolerance + trouble breathing and uneven heartbeats. I have been on Isentress and Truvada for 5 days. I feel terrible, the anxiety and insomnia are back, stronger, with loss of appetite, and I still feel pain in the chest area and unregular heart beats, have trouble breathing and sweat excessively. My questions : could these be a temporary condition due to the (new) switch ? Or could this be a sign of intolerance to Truvada ? (I'm really scared about these persistent difficulties with a third treatment, among other things by the tings I've read on lactic acidosis) What would you recommend ? Thank you
Response from Dr. Henry
Sounds quite frustrating. Lactic acidosis would be very rare on those combinations (and can be checked for with lab studies). A few patients are intolerant to Truvada-Epzicom can be used instead in patients who test HLA B5701 negative. Some patients experience a severe anxiety syndrome from various HIV meds that may need to be addressed in order to be able to work through some side effects and be able to benefit from long term control of HIV and maintenance of the T-helper cel count. We have seen patients who dont tolerate meds due to anxiety or trouble/pill swallowing phobia. In those cases we have utilized a number of approaches (counseling, deconditioning, hypnosis, and other modalities) to help patients work through initial problem (while monitoring carefully for any signs of other adverse events). KH
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