|Shift from viramune to...
Jul 9, 2013
I'm a 32 y/o man. CD4: 350 / VL: undetectable. My medication regimen is: viramune, 3tc and Viread. I take this regimen for 3 years and I am having some unpleasant side effects due to viramune. I wonder if I could replace viramune and maintain 3TC and Viread to my regimen.
My biggest fear is lipodystrophy and facial lipoatrophy, so I'd like to replace viramune by a medication that is not related to this side effect.I'd like to know what medication you think it could be then.
Thank you for reading my question. Greetings from Argentina, Pedro
| Response from Dr. Henry
Nevirapine actually usually looks pretty good regarding risk for lipodystrophy compared to other HIV drugs though good study comparing nevirapine to contemporary regimens are minimal since nevirapine getting much new use in US/Europe/Australia/Canada where many studies are done. I have little confidence that I can recommend an alternative to nevirapine that would for sure help matters. In older studies with nevirapine much of the fat problems may have been due to the AZT or D4T that nevirapine was used with. Unclear what your unpleasant side effects are that you attribute to nevirapine (usually well tolerated if or problems after first several months on the drug). A drug that might replace nevirapine in the US would be raltegravir (an integrase inhibitor) that appears to be one of the more fat friendly drugs but whether it would be better than nevirapine overall or in your case is uncertain to me-sorry I cant be more specific or helfpul. KH
Get Email Notifications When This Forum Updates or Subscribe With RSS
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.