How do you treat peripheral neuropathy if on Truvada and aluvia

Peripheral neuropathy is not common on Aluvia (Kaletra in US) and Truvada but it can happen. Priority is to make propoer diagnosis to determine nature of nerve problem and identify possible cause (ie nerve impingement, vascular/blood flow problem, vitamin deficiency, other infections (such as syphilis), other drug toxicities). HIV drug related peripheral neuropathy typically involves symmetric tingling/numbness and sometimes pain in toes them moving upwards. If it looks like the drugs are most likely cause the preferred approach is to switch off the offending medications. If meds need to be continued then a wide range of treatments can be tried that are variably helpful (from amitryptiline to gabapentin, ibuprofen, topical treatments, and narcotics pain meds in severe cases). KH