|changing Atripla to eviplera
Feb 27, 2013
Dear Dr. Henry, I have been told by my internist to change from Atripla (started: Dec 2010, cd4: 750-900 vl: undetectable, very good physical condition, age:38 gender:male) to eviplera as I have been showing signs of depression(only side effect experienced until now). My question: I would like to know if there are any risks involved and how will the transition from one med to the other will feel? Thanks in advance. Patient.
| Response from Dr. Henry
The efavirenz in Atripla can contribute to depression in some patients. Switching to Eviplera (Complera in US) is essentially a switch from efavirenz to rilpivirine which has a lower rate of central nervous system/psychiatric side effects (though still can occur). Rather than adding another drug to treat depression if one of the drugs you are taking is contributing to depression then often a switch to an alternative medication is often a reasonably plan to try on a trial basis. KH
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