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NNRTIs
Sep 30, 2012

Are either of the newer NNRTIs, Edurant or Intelence processed differently by the liver than the older drug Viramune? I have been on Viramune for more than 10 years just wondering of switching to one of the newer ones would be considered more liver friendly? Thank-you, W.

Response from Dr. Henry

The major liver concern with nevirapine is early on treatment. After 10 years the rate of liver problems on nevirapine would be expected to be low. Though etravirine and rilpivirine may be viewed as being more liver friendly there is minimal very long term data for those more recently approved NNRTIs. I view nevirapine as a safe drug for patients doing well on it after several years based on published data and experience in our clinic. KH



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