|Isentress and lexiva
Sep 21, 2012
After 11yrs on Trizivir, I have opted to change Meds and my Dr is recommending Isentress and lexiva! My Tcells count have alway been 900 to 980 and because of lypo on face I felt it was time for a change. While I'm doing some research on these two Meds, do you have any info or input on these two Meds "Isentress and Lexiva?"
| Response from Dr. Henry
The AZT in Trizivir is believed to contribute to increased risk for fat loss (lipoatrophy). Trizivir is not a preferred/recommended stand along HIV treatment in the US partly due to concerns about fat loss as well as initial/long term efficicy (though it sounds like in your case it has worked fine from HIV perspective). To my knowledge we dont have any patients in our large (1600+ patients) clinic nor am I aware of a study looking at use of raltegravir + fosamprenavir. Lexiva (fosamprenavir) is usually used with ritonavir boosting. Studies using only two active drugs (ie raltegraivr + a boosted PI) have been either small pilot studies or with equivocal or disappointing results so that approach is not recommended though there may be situations where it might work. KH
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