good evening doctor. thanks for replying my previous question.i started medication 40days back.initially had numbness and fever and rashes after 15 days so changed zidovidine300mg+lamivuidine150mg morning and night pill and one more efavirenz600mg night tablet. rashes appears on face neck leg chin almost all parts. after taking allergy tablets rashes complete gone in 3 days.i was happy . iam also feeling hang over till afternoon. but today when i woke and saw back there again small rashes appears on back of shoulder. i consulted doctor . she said it will be there for 3 weeks. iam really worried doctor.do i have to go to 2 regimen? is the medication not suited for my body.any idea to to overcome hangover in the morning ? iam 40 male cd4 346.thanks again doctor

Starting HIV medications can often be associated with flare-up of a variety of rashes (such as from folliculitis or seborrhea) partly related to immune reconstitution as well as short term rashes directly from a drug adverse reaction. Difficult to comment further without ore details/exam findings. The hung over feeling likely due to the efavirenz and is a persistent problems for a modest subset of patients (? 10-15%)--if taking at another time of the day doesnt help and the problem continues and remains annoying then a trial switch to an alternative drug (often nevirapine) might be worth considering. KH