TB while taking atripla
Jan 26, 2012
hi doc, which anti TB drugs are ok while on atripla? how long one can use atripla before resistance develops? 5 years or more? can u tell from ur experience? and finally how long a newly diagnosed can live with HAART? 10 years or more? regards.
Response from Dr. Henry
Standard treatment for drug sensitive TB usually involves use of a rifamycin (rifampin or rifabutin), isoniazid, and ethambutol or streptomycin. Of those drugs the major concern for a drug interaction with Atripla (efavirenz)is with the rifamcin. If rifampin is used, the levels of efavirenz may reduced threatening its effectiveness. Often, if rifampin is used then the dose of efavirenz is increased. Often rifabutin is used (typical dose is 450-600mg once daily)as the rifamycin when Atripla is being used for HIV treatment. If the viral load is suppressed then Atriple can often remain fully active for >> 5 years(no reason can last for decades for many patients). Life expectancy for newly diagnosed HIV infection depends on many factors (ie other diseases, smoking, age at diagnosis) but in general life expectancy for 20 year old with access to good treatment is measured in many decades. KH
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