Jan 4, 2012
I am on Atripla for 3 years. Undetectable, 560, under control. My question is I cannot eat 3 meals a day. I'm lucky if I eat at all, and have to force myself. I am losing weight, and am having muscle loss. I wake up nauseated, hungry, but just can't eat. Is there a hormone deficiency or something else going on? I have had Diverticulitis twice (2 yrs ago, and last sept). I have had an endoscopy (they took a biopsy, prescribed Prilosec) and a colonoscopy (fine, told me to come back in 10 years) I am 49. Drink, yes. Smoke, yes. But, I can't eat even though I am hungry. Is this related to Atripla? I get full instantly when I try. Before I was diagnosed, I ate 3+ full meals every day, and was losing weight (my primary care physcian said I was diabetic). I believe I was HIV pos for at least a year before then. I'm 5'8", 165 then, and going down now due to not eating.
I got laid off 2 1/2 years ago, went off Atripla for 3 weeks, then went on a 1 1/2 day regimin because I tried to extend it out, and it had no effect on me (regarding my numbers) for 3 months.
I cannot get confirmation of my (HIV TEST) western blot from the state of Arizona. They will not release that to me.
Since Atripla is (was) a newer treatment back then, are there any issues now showing up?
| Response from Dr. Henry
Challenging situation. Some patients can have ongoing central nerouvs systme problems from efavirenz or ongoing gut problems from efavirenz or tenofovir. If a thorough clinical evaluation does not find any other likely contributing factor and you have no history of drug resistance then a switch to alternative meds may be worth discussing on a trial baseis (ie Epzicom for Truvada if HLA B5701 negative and ralgegravir, an alternative NNRTI such as nevirapine or etravirine or rilpivirine, a boosted protease inhibitor, or even maraviroc for the efavirenz depending on your indvidual situation). KH
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