Sep 14, 2011
I've been on HIV treatment for 4 years Sustiva+Epzicom My VL is undetectable and my cd4 count is over 1000 health is good. During my recent visit to my doctor I told him that I had not been sleeping well and felt a little run down. He recommended replacing my Sustiva with the new Edurant...thus making my treatment Edurant+Epzicom. I have been reading that Edurant is for 1st time treatment only...Am I taking chances with this?
Response from Dr. Henry
There is little published information on use of rilpirvirine (Edurant) and Epzicom (most use with Truvada) or data on switching from efavirenz to rilpivirine in the setting of no prior drug resistance and undetectable HIV levels on efavirenz. Switching from efavirenz to rilpivirine in a situation like yours seems reasonable and likely to work for most patients with no prior drug resistance or concerns about use of anti-acid drugs (like proton pump inhibitors)or requirement to take with a meal (high fat recommended). If your baseline viral load was high (>100,000) then there may be some increased concern about use of rilpirivine but data on that is sparse. KH
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