Aug 24, 2011
I was diagnosed 2 years ago and, with Atripla, my CD4 slowly went to 78 (6%) to 223 (17%) and undetectable viral load since my first bloodwork. Last month's quarterly bloodwork showed a drop in both CD4 (125) and percentage (7%). A week later, my doctor redid the test and the numbers were 188 and 9%. She feels that I've become allergic to Bactrim because of the low CD4 and an unexplained low fever I was running for a couple of weeks. I stopped Bactrim and the fever disappeared within days, so maybe she was right. I can't find much about this online so I must ask: how can one suddenly become allergic to a med?
She did Dapsone to my meds list, FYI.
| Response from Dr. Henry
Some patient can become sensitive to sulfa drugs such as Bactrim with fever and in some cases Bactrim like drugs can also impact bone marrow function. I dont have an easy answer as to why such problems can occur after years of use (the effect of Bactrim on bone marrow function/CD4 count can build up slowly--the fever all of a sudden is less easy to explain unless there was some other cause for it that wasnt recognized but got better within time frame of stopping the Bactrim). Bactrim/sulfa allergies are more common in HIV+ persons than in the general population for reasons that remain poorly understood. KH
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