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Why Does HAART Decrease Hemoglobin A1c?
Jun 10, 2011

Hi. I recently read that diabetics taking HAART have lower Hgb A1c than diabetics who don't. I can't find any articles to explain this. Why does this happen? Does it mean that their diabetes is better controlled? If not, should we use a different cut-off to interpret the results in HIV (+) diabetics? I really appreciate your help. I love this website, especially Ask the Experts. Thanks. --Baffled in the Bronx

Response from Dr. Henry

I follow the metabolic literature in the setting of HIV infection fairly carefully and I have not seen any convincing published data that effective HAART consistently lowers the HgA1c. Since most patients gain some weight on HAART (sometimes termed a return to health) the HgA1c would not be expected to significantly decrease (some regimen esp older ones may actually impair glucose metabolism and can trigger diabetes). If any reader has a reference please post. KH

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