|Does Ritonavir increase levels of norspan in body?
May 18, 2011
G'day. I am looking to find out specifically if ritonavir increases the level of norspan (pain patch) in my body. I am currently on abacavir, neveripine, 3tc, presista, ritonavir for hiv. I am experiencing >10 kilos weight loss (unexplained even with CT Scan and U/S). My HIV Dr. is advising that my norspan patch (10mg per/hr)could be interferring with my HIV meds and the cause of my weight loss. I disagree and am looking for evidence to support/reject his opinion. I was weighing in March 2011 approx. 92 kilos. I now weigh 77 kilos and feel healthy despite the loss. Nothing is showing up on scans to indicate other possibilities. Any ideas would be appreciated.
| Response from Dr. Henry
Protease inhibitors often would increase the levels of buprenorphine (norspan) possibly leading to toxicity that might include central nervous system effects. I am unsure how that might directly related to weight loss unless depression or decrease appetite were triggered by excessive high levels of Norspan. KH
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