Atripla and bone
Mar 11, 2011
what are the effects of atripla on bone density? and if there is an effect how long dose it usually take to notice it?
Response from Dr. Henry
It appears that many effective HIV regimens results in a modest loss of bone density in the first year of use and then the bone density stabilizes. Tenofovir containing regimens (such as Atripla) may continue to have a variable slow loss of bone density (ie 1%/year range) that is generally of uncertain clinical significance over the first 5+ years of use. There may be a small subset of patients that may have more serious bone loss (< 5%). Vitamin D and calcium supplementation and obtaining a DEXA scan are useful measures in many setting to minimize and assess bone density concerns. KH
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