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Fat distribution with Prezista
Feb 23, 2011

Hi I am a 55 year old man who has been on medication since 2005. I have had a number of different medication regimes which have had various unwanted side effects. I am currently on 2 x Prezista + 1 x Truvada + 1 x Norvir. CD4 and viral load are bothh very good but I have gained significant (and unsightly) weight around the belly - I look pregnant. Is there another similar regime that could provide all the good results from my current one without the 'pregnancy'.

Response from Dr. Henry

The level of fat gain with your current regimen usually compares favorably to other effective regimens. There is little data about whether switching off your current regimen to an alternative (possibilities include raltegravir, mariviroc, or a NNRTI such as nevirapine or etravirine) would significantly impact fat gain. Often fat gain is seen in the first year of many regimens (sometimes called the return to health phenomenon often 5-10 pounds). Genetics can play a strong role (compare your body habitus to relatives) as can diet/exercise habits. KH

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