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Does ANY lipodystrophy or lipoatrophy develop from PEP course?
Jan 26, 2011

I am currently on a 28 day course of combivir and kaletra. Has there been ANY reported cases at all of any level of lipoatrophy and/or liposystrophy from this short term PEP treatment?

I started today and am nervous about the gastrointestinal side effects as I heard they can be quite severe in people. But I'm most concerned about any lipodystrphy and lipoatrophy as that also seems progressive and irreversible once it starts.

Thanks so much for all you guys do on the site!

Response from Dr. Henry

Significant lipodystrophy from a 28 day course of Kaletra/Combivir is extremely unlikely to occur-I have not observed it nor am I aware of any published well documented case. Also, mild/early lipodystrophy is often stabilized or reversed when the offending drugs are stopped. KH

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