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Please post this (multivitamins and antacids can interfere with ARV absportion)
Nov 28, 2010

On another forum that shall remain nameless, the expert said that a multivitamin will not interfere with ARVs. While this might be true for most of them, it is not true for integrase inhibitors. The person asking the question had switched to Isentress from another regimen and saw his viral load increase. He was taking multivitamins with his pills. Polyvalent cations such as magnesium or calcium can profoundly affect absorption of integrase inhibitors, especially when they are included in the doses contained in antacids. Studies have shown this quite clearly and people on regimens including integrase inhibitors must be made aware of this possible complication. Experts recommend that any supplement containing polyvalent cations be taken at least 4 hours from an ARV regimen containing an integrase inhibitor.

Response from Dr. Henry

I havent seen any published data documenting significant interference with absorption of raltegravir due to standard multi-vitamins. If any reader knows of such a reference please post. KH

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