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new hope of a cure for HIV
Oct 27, 2010

AUSTRALIAN scientists have revealed the most complete picture yet of the way HIV maintains its grip on the body, pointing to new ways to combat it. The Melbourne-based research has explained how the virus hides dormant versions of itself in a reservoir of cells out of the reach of conventional treatments but still able to "wake up" in the future, posing a major hurdle to any total cure for HIV.

"Once HIV gets into these cells, the virus can then go to sleep," said Co-Head of the Burnet Institute's Centre for Virology and Director of the Alfred's Infectious Diseases Unit, Professor Sharon Lewin.

"These silently infected cells are not cleared by anti-HIV drugs or the immune system (meaning) once a patient stops the anti-HIV drugs, the virus can then wake up and gets going again.

"Understanding this mechanism will enable new treatment options to be developed which could block latent infection."

Start of sidebar. Skip to end of sidebar. Related CoverageNew findings impact HIV drug use The Australian, 27 Jul 2010 New hope in fight against AIDS pandemic The Australian, 20 Jul 2010 Anti-HIV gel could cut risk by up to 54pc Adelaide Now, 20 Jul 2010 Scientists discover AIDS breakthrough Adelaide Now, 8 Jul 2010 Australian discovery stemmed The Australian, 14 May 2010 .End of sidebar. Return to start of sidebar.

The research is published in the journal Proceedings of the National Academy of Science this week.

Prof Lewin said it had remained a mystery as to how the virus gained access to the body's resting CD4-T cells and how it could then lie hidden for years despite prolonged treatment with anti-HIV drugs.

"Our team of researchers has now identified the path by which the virus can infect resting CD4-T cells and establish latency," Prof Lewin said.

"We have shown that a family of proteins, called chemokines, that guide resting cells through the blood and into lymph node tissue can 'unlock the door' and allow HIV to enter and set up a silent or 'latent' infection."

Prof Lewin said understanding how the virus achieved this should speed up the development of new and more potent treatments for HIV, that could possibly block the virus from establishing latency while also targeting its more active presence in the body.

Professor Brendan Crabb, Director of the Burnet Institute, said the breakthrough was a long time coming and heralded the beginning of a new chapter in the fight against HIV and AIDS.

"We (the global scientific community) have been working on HIV for close to 30 years and it's really only now that we're beginning to see that a cure for HIV might be achievable and needs to be a major scientific priority," Professor Crabb said.

Hi Dr keith is this good news for a cure ???

The research was a collaborative effort involving scientists from the Burnet Institute, The Alfred, Monash University, University of Montreal, Canada and the Westmead Millennium Research Institute in Sydney

Response from Dr. Henry

That work is interesting from the scientific standpoint but it is unclear to me what is the immediate clinical relevance particularly regarding chances for increasing the odds for a practical cure for HIV infection in the decade ahead. KH

side effects with Norvir Reyataz and Truvada
Viread and Videx combo

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