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Isentress and sleepless nights
May 14, 2010

I recently switched my hiv regiman of Truvada, Reyataz, and Novir that I had been on for two years, to Isentress (twice a day) and Truvada. I switched to try to minimize the any lypo. This is my 12th day on isentress. All is fine other than sleep. I know that one of the side effects of isentress can be disrupted sleep. Since starting isentress, my sleep has been minimal, only getting about 4 hours of light sleep (normal with sleep aid is 7 to 8) then waking up and not being able to go back to sleep. Is this a temporary thing while my body adjust to the new med? I'm already taking lunesta nightly, but the isentress is trumping the sleep aid. Thanks

Response from Dr. Henry

Good question. The natural history/evolution of sleep disturbances linked to raltegravir is not well described so difficult to state with any certainty what may happen in your case. I have had several patients report that the sleep problem persisted while others have noted improvement with time. After several months if still a major issue might merit sleep evaluation and or consideration of switching off the raltegravir if no other explanation forthcoming. If any reader knows of a reference on the matter please post. KH

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