Nov 18, 2009
Hi I was diagnosed in June, and began a regimen of Truvada, Lexiva and Norvir. My viral load is 60 (and dropping)and 2 months ago my T cells were 390(probably higher now). A couple of months in I noticed my stomach becoming bloated, I'm guessing due to visceral fat. I've read that this can be a side effect of PIs. My question is would changing my regimen to non PI medications possibly reverse this effect? And if so, what regimen would you recommend?
| Response from Dr. Henry
The bloating is more likely due to gas than rapid accumulation of fat (relatively uncommon with your current regimen). A clinical examination and sometimes X-rays (such as abdominal CT scan) can sort out the cause. Gas from either the protease inhibitors or tenofovir can cause bloating /fullness. If dietary and symptomatic measures and time don't see some improvement then a switch off the PI to a NNRTI (such as efavirenz or nevirapine) or an integrase inhibitor (such as raltegravir) could be considered as well as from Truvada to Epzicom (if HLV B5701 negative ) if the tenofovir appears to contribute to the abdominal fullness. KH
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