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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
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Unusual side effects with Isentress
Nov 7, 2009

Hello Doc. Thanks for answering my question Current regime: Isentress (twice a day) and Truvada Previous regime: 3TC, VIread and Sustiva for 4 years I have switched some of the meds because was tired of Sustiva side efffects such as insomnia, dizziness, vivid nightmares etc. Now since I have started this new regime 9 months back, I have terrible muscle tension headaches, unusual tiredness and fatigue and paresthesia. My doctor have suggested I can switched Isentress to Intelence or be back on Sustiva for about 12 to 14 days to see if Isentress is causing all these undesired effects. I am currently relunctant to start with a new drug at this time and I am thinking going back on Sustiva for 2 weeks. I guess I will have to go through all the side effects of the beginning all over again. What is your advise?? Thanks again

Response from Dr. Henry

Raltegravir can sometimes cause headaches. Perhaps a trial of a boosted protease inhibitor might also be considered (such as ritonavir + darunavir or atazanavir) depending on your past treatment and resistance history. My patients often do well with such regimens and a month trial in the setting of suppressed virus may be worth it to sort out that annoying side effect for you. KH


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