Jul 29, 2009
my v.l is not detected and i do not take med for hiv till now. but i have also c&b . i have finished my treatment for c (interferon and ribavirin) since 22 days and my pcr is negative (zero) i still taking zeffix for virus b 100 mg once every day and my pcr for b is negative (zero) . my cd4 drob on interferon from 915 to 436 but cd4% was the same . after finished my C treatment i thought that my cd4 will increase but it was down to 318 (18%). is that because i take zeffix? i need your advise. or that because interferon ? can i stop zeffix? or wait few monthes and my cd4 will be ok? and what is the contact betwwen zeffix and cd4? thank you very much.
| Response from Dr. Henry
Zeffix (low dose lamivudine) is not generally recommended for monotreatment of hepatitis B due to concerns about resistance developing from HIV standpoint. If you are an elite controller (low or negative HIV levels without treatment) then that might be a special situation for which data is very limited. Use of lamvudine for hepatitis B often would be monitored with hepatitis B tests (such as hepatitis B DNA levels). There likely would be little direct effect of low dose lamivudine of CD4 levels in a situation as you describe (CD4 count often drops on hepatitic C therapy and may take a while to rebound). KH
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